Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19 medrxivpreprint GIESGhent ResearchUGent ugent interleukin research covid COVID19 SARSCoV2 medical news drug
By Bhavana KunkalikarMar 30 2023Reviewed by Lily Ramsey, LLM *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
In addition to supportive interventions, the management of COVID-19 during the hyperinflammatory phase involves the administration of corticosteroids, as well as IL6 and Janus kinase inhibitors. The complement cascade is a crucial and versatile component of the innate immune system. In 2020, two multicenter clinical trials were conducted, which involved the enrollment of hospitalized COVID-19 patients exhibiting hypoxia. The COV-AID study enrolled individuals with elevated levels of inflammatory serum markers.
The study involved comparing patients who did and did not experience a critical disease course characterized by the requirement for mechanical ventilation or mortality at any point. The sC5b-9 molecule exhibited hierarchical clustering with primary inflammatory cytokines, including interferon-gamma , tumor necrosis factor-alpha , and IL-6. The study indicated that the correlated markers were significantly higher in individuals who died than those who didn't, implying that complement plays a crucial role in COVID-19-associated inflammation.
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