Do two or more mRNA vaccine doses provide additional protection in patients with prior COVID-19 infection? MayoClinic mRNA vaccine vaccination COVID19 coronavirus covid infection
By Neha MathurMar 30 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in the Open Forum Infectious Diseases, researchers conducted a retrospective cohort study among vaccinated and unvaccinated coronavirus disease 2019 patients between December 16, 2020, and March 15, 2022, in the United States of America .
About the study In the present study, researchers investigated the risk of COVID-19 in vaccinated and unvaccinated individuals with and without prior infection. They depicted the frequency of COVID-19 across all study groups using a Simon-Makuch hazard plot. Likewise, they used multivariable Cox proportional hazards regression to assess the correlation of patient demographics and prior infection & vaccination status with new reinfections.
Results The study comprised 101,941 subjects, of which 55% were female, and 5,957 individuals had suffered at least once from COVID-19, with the average time between infection and the beginning of the study being 40 days. In total, 71% of the study population received an mRNA COVID-19 vaccine, either BNT162b2 or mRNA-1273, by the end of the study. All study participants had comparable socio-economic demographics.
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Omicron VOC was predominant worldwide in early 2022. Studies showed that boosting patients with prior COVID-19 provided additional immune protection against severe disease at 39.3% vaccine effectiveness .
The decline in the cumulative infection risk from Delta or Omicron VOCs post-receiving ≥2 doses of the mRNA vaccines in a previously infected cohort was notable. The people comprising this cohort had COVID-19 before December 16, 2020, i.e., in the pre-Delta phase. A vaccine well-aligned to the predominant SARS-CoV-2 VOC was anticipated to confer substantial additional protection even in people who contracted the disease long ago. So, the study findings also favor the recommendations for bivalent vaccines based on ancestral strain and Omicron BA.4/BA.5.
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