New study challenges the idea that early Parkinson'sdisease causes cognitive dysfunction MUSCHealth
results from the Parkinson's Progression Markers Initiative on nearly 400 individuals, including 253 newly diagnosed PD patients and 134 healthy controls. Within the cohort, 84 of the individuals were identified as having pre-existing mild cognitive impairment. PPMI conducted a battery of tests on memory, visuospatial functions, processing speed, working memory and verbal fluency.
The results were contrary to the team's expectations, particularly with regard to PD patients who were already experiencing mild impairment, Turner said. The data suggested that even those already affected suffered little-to-no further cognitive decline during the first five years after diagnosis. "Early cognitive decline is commonly reported by PD patients. There have been a lot of neuro-protective trials that look at non-motor symptoms like anxiety, depression and cognition, but no one had looked at this robust data set before," he said.Previous tests on Parkinson's disease patients have produced a variety of results, some even somewhat contradictory according to Turner, but they lacked the controls or the sample size that his study included.
Another review employing the MOCA screening test produced similar findings as Turner's study, but with a single measure that offered a more global view of the disease's impact rather than his team's more specific findings.
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