Researchers identify a potential new therapeutic target in Parkinson'sdisease NatureComms
Further investigation is warranted to fully explore potential limitations of treatment with PDpep1.3. As with other therapeutics in development for neurological diseases, a detailed determination of the spatial and temporal kinetics within neurons will be required to fully understand target engagement. This will also require mapping out when in the feed forward cycle of endolysosomal dysfunction the intervention will be most efficacious.
The a-syn competition assay had a constant 50 nM concentration of FITC-PDpep1.3 peptide and 1 μM of CHMP2B; a-syn was serially diluted 1:1 starting from 30 μM. Plates were incubated for 30 min at room temperature before reading. Raw FP data in millipolarization units were fitted to the following equation in Graphpad PRISM 8:is the concentration of CHMP2B.
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