What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion? univ_paris_cite biorxivpreprint Cholesterol SARSCoV2 COVID19 Spike SpikeProtein
By Bhavana KunkalikarDec 20 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of ceramide and cholesterol on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 spike protein.
The ability of FP1 and FP2 present in the SARS-CoV-2 S protein to promote the fusion of two liposome groups by simulating viral envelope and cellular membranes , respectively, was used to assess their fusion activity in vitro. The team utilized synthetic peptides having a C-terminal His6 tag that allowed chemical binding to nitrilotriacetic acid-nickel lipids within the liposome membrane. A fluorescence resonance energy transfer -based lipid mixing test was used to assess fusion.
Results Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy A subpopulation of v-liposomes was found to have NTA-Ni lipids in their bilayer, while the c-liposomes did not. This facilitated the exclusive anchoring of FP1 and FP2 to the v-liposome surface. Under the same experimental settings, FP1 promoted a strong fusion of PC v- and c-liposomes, while FP2 had no discernible effect.
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