Vaccination-induced responses for Omicron subvariant neutralization medrxivpreprint Helmholtz_HZI Vaccination Omicron SARSCoV2 COVID19 Coronavirus Neutralization
By Pooja Toshniwal PahariaSep 20 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers summarized existing data on severe acute respiratory syndrome coronavirus 2 Omicron variant’s sub-variant neutralization. They also performed a comparative assessment of cross-neutralizing responses of Omicron subvariants in comparison to the Wuhan-Hu-1 strain antigen.
Databases such as PubMed, medRxiv and bioRxiv were searched between 26 November 2021 and 25 July 2022, for studies evaluating post-COVID-19 vaccination neutralizing Ab responses to Omicron subvariants. The study was ancillary to a literature review. It included only published studies or preprints assessing nAb responses for ≥1 Omicron subvariant induced by a World Health Organization -approved COVID-19 vaccine.
The nAb titers induced after primary vaccinations and booster vaccinations were similar for all Omicron subvariants, except BA.4/5 for which fold-reductions were higher in relation to Omicron BA.1. Omicron subvariant-wise percentages of responders were low after primary COVID-19 vaccination in comparison to the Wuhan-Hu-1 strain . Still, they increased after booster vaccinations .
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