Since monkeypox began spreading in the U.S., thousands put their trust in a vaccine that hasn't undergone trials to see how well it fights the virus in humans. It was designed to prevent smallpox, and studies show it works against monkeypox — in animals.
, adding yet another layer of uncertainty to the rollout now that people are receiving less vaccine.
“We’ve neglected this disease in Africa for many, many years,” said David Heymann, a professor of infectious disease epidemiology at the London School of Hygiene and Tropical Medicine during a recent briefing by the American Public Health Association and the National Academy of Medicine. Decades after it was first asked, he noted, the question remains: “Will human monkeypox replace smallpox? ... We still don’t know.
Later, Bavarian Nordic developed Jynneos as a safer option. Determining its efficacy for smallpox was based on the amount of antibodies it produced, compared to ACAM2000, and it was also tested against monkeypox in animals. Last year, Rimoin received funding from the U.S. military’s Defense Threat Reduction Agency to work with countries in Central Africa where monkeypox is endemic to improve surveillance of the disease, how outbreaks are investigated, and create a training hub. The project, called the Monkeypox Threat Reduction Network, has enough funding “to get things off the ground,” she said, but it’s not enough to do this work across the region.
The National Institute of Allergy and Infectious Diseases , part of the National Institutes of Health, is in the process of setting up clinical trials to study what level of antibodies the vaccine — administered both in full and partial doses — generates in the population, in the event the virus spreads widely.
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