Vaccines inhaled through the mouth or nose might stop the coronavirus in its tracks, although there’s little evidence from human trials so far.
That’s the hope of dozens of research groups and companies working on new kinds of inoculation. Rather than relying on injections, these use sprays or drops administered through the nose or mouth that aim to improve protection against the virus SARS-CoV-2.
Evidence in animals supports the idea that sterilizing immunity can be induced against COVID-19, although data from humans are scant.explains why mucosal vaccines might help to quash SARS-CoV-2, and what the latest findings mean.The COVID-19 vaccines currently in use do a good job of reducing disease severity and preventing hospitalization, but don’t block mild illness or transmission that well.
Researchers are testing mucosal vaccines as first doses for unvaccinated people and as boosters for those who have already received COVID-19 shots. Some mucosal vaccines are identical to injected vaccines, but are squirted as liquid or droplets up the nose. Others have a different composition, or are prepared differently.
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