Smartphone videos of the sit-to-stand test predict osteoarthritis and health outcomes in a nationwide study NaturePortfolio
; digital tools meant for health evaluations may benefit from additional model training with a diverse sample of participants , particularly those with movement conditions like osteoarthritis, performing the activity of interest.
In summary, we developed a digital tool to automatically measure STS times and kinematics from at-home videos, deployed it in a nationwide study, and found that measurements from at-home videos are sensitive enough to predict physical health and osteoarthritis.
. In the sample of individuals used in the final analysis , the mean age was 37.3 ± 17.8 years, ranging from 18 to 96 years, and 53% were female (Supplementary Table
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Previous BCG vaccination is associated with less severe clinical progression of COVID-19 - BMC MedicineBackground BCG vaccination, originally used to prevent tuberculosis, is known to “train” the immune system to improve defence against viral respiratory infections. We investigated whether a previous BCG vaccination is associated with less severe clinical progression of COVID-19 Methods A case-control study comparing the proportion with a BCG vaccine scar (indicating previous vaccination) in cases and controls presenting with COVID-19 to health units in Brazil. Cases were subjects with severe COVID-19 (O2 saturation | 90%, severe respiratory effort, severe pneumonia, severe acute respiratory syndrome, sepsis, and septic shock). Controls had COVID-19 not meeting the definition of “severe” above. Unconditional regression was used to estimate vaccine protection against clinical progression to severe disease, with strict control for age, comorbidity, sex, educational level, race/colour, and municipality. Internal matching and conditional regression were used for sensitivity analysis. Results BCG was associated with high protection against COVID-19 clinical progression, over 87% (95% CI 74–93%) in subjects aged 60 or less and 35% (95% CI − 44–71%) in older subjects. Conclusions This protection may be relevant for public health in settings where COVID-19 vaccine coverage is still low and may have implications for research to identify vaccine candidates for COVID-19 that are broadly protective against mortality from future variants. Further research into the immunomodulatory effects of BCG may inform COVID-19 therapeutic research.
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