The tech could someday be used in human organs.
The pigs had already been dead for an hour, and yet, the cells of their hearts, brains and livers were still kicking.
And in theory, such a device could also be used in living humans to treat ischemia that occurs during a stroke or heart attack, Dr. Robert Porte, a professor in the department of surgery at the University of Groningen in the Netherlands who was not involved in the study, wrote in an accompanying commentary of the work.Related: How long can organs stay outside the body before being transplanted?
The team plans to study OrganEx in many more animal studies"before even thinking about translating" the technology to humans, Dr. David Andrijevic, an associate research scientist in neuroscience at the Yale School of Medicine and co-first author of the study, said at the briefing. "Cells actually don't die as quickly as we assume that they do, which basically opens up a possibility for intervention," Dr. Zvonimir Vrselja, an associate research scientist in neuroscience at the Yale School of Medicine and co-first author of the study, said at Tuesday's press briefing. In other words, if scientists can step in soon enough, they can save some cells from certain doom.
After six hours, the team found that ECMO didn't sufficiently perfuse all the animals' organs with blood and many blood vessels had collapsed, as they typically would after death; the ECMO-treated animals also showed extensive signs of hemorrhage and tissue swelling. By comparison, OrganEx reduced the degree of cell death and improved the preservation of tissues throughout the body.
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