Scientists isolate two antibodies that neutralize all current SARS-CoV-2 variants of concern biorxivpreprint antibodies neutralizing monoclonal covid COVID19 SARCoV2 VOC variants variantsofconcern research
By Dr. Liji Thomas, MDApr 11 2023Reviewed by Lily Ramsey, LLM In a recent study on the bioRxiv preprint server, researchers found antibodies that neutralize all current severe acute respiratory syndrome coronavirus 2 variants of concern by conformational locking.
This is due to its documented ability to evade existing antibodies. A recent preprint reported two antibodies that neutralize all known virus variants, including the most recent Omicron variants. The latter was useful in protecting immunocompromised individuals against the virus despite their poor response to the vaccines. The failure of this formulation to protect against the newer Omicrons subvariants highlights the need to find potent broad-spectrum antibodies against the virus in its current and future avatars.
Related StoriesThese antibodies were isolated from serum samples taken from convalescing COVID-19 patients. Their binding causes the RBD to lock in the "down" position, thereby interfering with virus binding even though they bind to the side of the spike protein. …the antibody and its CDRH3 forms a 'wedge' between SD1 and NTD that prevents the conformational rearrangement necessary for RBD to reach the up conformation.
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