The University of British Columbia researchers have discovered a key vulnerability of major coronavirus variants. The University of British Columbia researchers uncovered a key vulnerability in all main variants of the SARS-CoV-2 virus, including the newly discovered BA.1 and BA.2 Omicron subvarian
The University of British Columbia researchers have discovered a key vulnerability of major coronavirus variants.virus, including the newly discovered BA.1 and BA.2 Omicron subvariants.
Neutralizing antibodies can target the vulnerability, potentially opening the door for treatments that would be universally effective across variants., uses cryo-electron microscopy to identify the atomic structure of the vulnerable region, or epitope, on the virus’ spike protein. The study also reports a VH Ab6 antibody fragment that can bind to this location and neutralize every major variant.
This new paper identifies the antibody fragment VH Ab6 as the “master key,” which has been found to be effective against the Alpha, Beta, Gamma, Delta, Kappa, Epsilon, and Omicron variants. By binding to the epitope on the spike protein and preventing SARS-CoV-2 from infecting human cells, the fragment neutralizes the virus.
By mapping the molecular structure of each spike protein, the team has been searching for areas of vulnerability that could inform new treatments.
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