People with genetic predisposition to obesity may have lower risk of cardiovascular disease

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People with genetic predisposition to obesity may have lower risk of cardiovascular disease
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People with genetic predisposition to obesity may have lower risk of cardiovasculardisease TheLancet

The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report inThere has been a global increase in the incidence of overweight and obesity over the past few years. Almost one-third of the world's population now lives with overweight or obesity.

"The figure is alarming, since it is well-established that a high BMI in middle-age increases the risk of developing cardiovascular disease and other conditions," says Ida Karlsson, assistant professor at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. However, according to this new study, the risk of developing cardiovascular diseases varies widely among people with obesity. The researchers used data from over 15,000 twins from the Swedish Twin Registry, gathering information about their BMI and theirfor high BMI. They also used data from medical registries to establish the incidence of cardiovascular disease in this group.

By analyzing this information, the researchers were able to study how overweight and obesity as a result of genetic versus environmental and"The link between obesity and cardiovascular disease was twice as strong in those with a genetic predisposition to a low BMI as it was in those with obesity driven by genetic factors," says the study's last author, Ida Karlsson.

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