The study found that single-dose ethanol intoxication causes acute and long-lasting neuronal alterations in the brain. Researchers from the Universities of Cologne, Mannheim, and Heidelberg have shown that even a single alcohol dose permanently changes the morphology of neurons. In particular, alco
have shown that even a single alcohol dose permanently changes the morphology of neurons. In particular, alcohol affects the synapses’ structure as well as the dynamics of the mitochondria, the cell’s powerhouses.
The working hypothesis was that a single administration of ethanol would create a positive connection with alcohol, similar to how memories are created after a single lesson. The morphological remodeling of neurons is a well-known basis for learning and memory. These so-called cellular plasticity mechanisms, which are central to learning and memory, are also thought to be at the core of the formation of associative memories for drug-related rewards.
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