Omicron BA.1/BA.2 breakthrough infection after 3-dose BNT162b2 vaccination provides improved protection against Omicron BA.5 Omicron Coronavirus Disease COVID BA5 UniSouthDenmark CDC_NCEZID
Research Letter: Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections. Image Credit: Jo Panuwat D / Shutterstock
About the study In the present study, researchers examined authentic viral neutralization capacity between those who received three-dose BNT162b2 vaccination regimens to those who were immunized and later infected with SARS-CoV-2 Omicron BA.1/BA.2 subvariants. Results Serum samples from the vaccinated cohort showed neutralization of Omicron BA.5 subvariant at a median PRNT90 titer of 20. In contrast, serum samples of the convalescent cohort displayed BA.5 neutralization at a median PRNT90 titer of 160. Furthermore, Wilcoxon rank-sum test indicated that this eight-fold rise in neutralization following Omicron infection had statistical significance. Additionally, the convalescent cohort displayed neutralization of SARS-CoV-2 Delta and Omicron BA.1/BA.
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