Semaglutide hit the market with fanfare but has since left patients and healthcare providers frustrated.
. Tirzepatide is a related GLP-1 receptor agonist that also adds a second incretin-like agonist activity that mimics the glucose-dependent insulinotropic polypeptide.
Despite tirzepatide's current approval only for type 2 diabetes, Varney has been successfully prescribing it to patients without diabetes off-label for weight loss. "We try to only prescribe agents that patients can continue to access," says Fitch, who has had some patients with commercial insurance start on Wegovy with coupon discounts only to later lose access.
Semaglutide in Canada goes for about $300 for a 4-week supply, roughly a quarter the US price, she says, but is"still too high for many of my patients."
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