When compared to standard treatment, the combination of ramucirumab and pembrolizumab decreased the risk of mortality by 31% in patients with advanced non-small cell lung cancer that had progressed on previous immunotherapy. According to a study done under the Lung Cancer Master Protocol (Lung-MA
When compared to standard treatment, the combination of ramucirumab and pembrolizumab decreased the risk of mortality by 31% in patients with advanced non-small cell lung cancer that had progressed on previous immunotherapy.
The hazard ratio for overall survival time for patients on the investigational arm versus the standard of care arm was 0.69 . The two arms’ respective median OS times were 14.5 and 11.6 months.and were also presented at the American Society of Clinical Oncology 2022 annual conference in Chicago . “This is the first trial to show a survival benefit with ICI and VEGFR inhibition for patients with advanced lung cancer who have experienced tumor progression on prior ICI,” Reckamp said.
The trial accrued rapidly and with a diverse population, in large part because of the robust outreach of the Lung-MAP master screening protocol. Roy S. Herbst, MD, Ph.D.
Treatment on the trial’s control arm was chosen by the physician and patient from among a set of four standard chemotherapy options: docetaxel plus ramucirumab, docetaxel alone, gemcitabine, or pemetrexed. Approximately two-thirds of patients on standard therapy received docetaxel and ramucirumab as the most active therapy approved in this setting.
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