Biomarkers of misfolded proteins are found in the blood by a sensor. Before the first clinical symptoms appear, Alzheimer's disease has a 15–20 year symptom-free period. A research team has discovered that it is possible to detect Alzheimer's disease in the blood up to 17 years before any outward s
Biomarkers of misfolded proteins are found in the blood by a sensor.disease has a 15–20 year symptom-free period. A research team has discovered that it is possible to detect Alzheimer’s disease in the blood up to 17 years before any outward symptoms start to show. This is done by using an immuno-infrared sensor developed in Bochum. The sensor detects the protein biomarker amyloid-beta misfolding.
. This finding is backed by a comparative study that was conducted using complementary single-molecule array technology and published in the same journal on March 2, 2022.Early detection of symptom-free people with a high risk of Alzheimer’s diseasefrom participants in the ESTHER study conducted in Saarland for potential Alzheimer’s biomarkers. Blood samples were collected and frozen between 2000 and 2002.
“Unlike in the clinical phase, however, this marker is not suitable for the early symptom-free phase of Alzheimer’s disease,” as Klaus Gerwert summarises the results of the comparative study. “Surprisingly, we found that the concentration of glial fiber protein can indicate the disease up to 17 years before the clinical phase, even though it does so much less precisely than the immuno-infrared sensor.
“We plan to use the misfolding test to establish a screening method for older people and determine their risk of developing Alzheimer’s dementia,” says Klaus Gerwert. “The vision of our newly founded start-up betaSENSE is that the disease can be stopped in a symptom-free stage before irreversible damage occurs.”
To date, plaques have been detected directly in the brain using the complex and costly PET scan technology, or indirectly utilizing protein biomarker concentrations in invasively obtained cerebrospina fluid using ELISA or mass spectrometry technologies. Unlike conventional plaque diagnostics, the immuno-infrared sensor detects the earlier misfolding of amyloid-beta, which results in later plaque deposition.
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