Research led by the Université Paris Cité, CNRS, France, has investigated factors driving variability in diverse immune responses to SARS-CoV-2.
In a paper,"Dissecting human population variation in single-cell responses to SARS-CoV-2," the team used single-cell RNA sequencing to analyzefrom diverse populations, comparing responses to SARS-CoV-2 against factors like genetics, age, sex, and comorbidities.
As an environmental factor, exposure to a virus can be a local or regional occurrence. Without knowledge of these exposures, immune response differences could be correlated to ancestry. The authors warn that this could lead to overestimating the effects of genetic ancestry on immune response variation.
The researchers also identified previously unreported signals of Neanderthal introgression affecting immunity phenotypes. For example, a gene variant that decreases post-translational modification responses to SARS-CoV-2 and IA was found in 38% of Europeans and 22% of East Asians.
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