🆕 data on oral minocycline answer a long-held question about the drug's potential to help with geographic atrophy. ARVO2023 MacularDegeneration AMD
The immune-targeting drug didn't slow the atrophy's expansion across the macula, according to new findings presented at the 2023 annual meeting of the Association for Research in Vision and Ophthalmology in New Orleans.
Ophthalmologists have long wondered if an antibiotic like minocycline could be used to target the activated microglia cells, the innate immune cells that can drive or resolve inflammation and that appear at or near"the scene of the crime" in AMD patients, Keenan said. A total of 46 adverse events attributed to the treatment were reported, including increased concentrations ofAlthough the results were disappointing,"this is not a surprise because it's a very difficult nut to crack, geographic atrophy," said Demetrios Vavvas, MD, PhD, professor of ophthalmology at Harvard Medical School and director of the Retina Service at Mass Eye and Ear in Boston.
"So, there's still an unmet need," Keenan stressed, adding that patients need a more effective treatment with a lower risk profile.
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