Researchers develop new lower cost, dual-modality imaging technique to facilitate earlier disease detection uofigrainger NatureComms
. The algorithm calculates all distances between all microbubbles in the current frame and all microbubbles in the next frame. Then the algorithm minimizes the total distance and finds the optimal pairs of microbubbles in adjacent frames. Applying the algorithm to all frames can give us the collections of a series of microbubble tracks. Because of the fast blood flow speed, microbubbles cannot always remain in the field of view.
The oxygen-challenge protocol of kidney imaging was as follows. During the imaging, 100% oxygen was used for 50 sec, then a mixture of 3% oxygen and 97% nitrogen was used for 50 sec, and finally, the mixture was changed to 20% oxygen and 80% nitrogen. To validate that ICG was delivered into the lymph node, we used an IVIS spectrum imaging system to check the ICG biodistribution. An excitation filter centered at 745 nm and an emission filter centered at 800 nm with 2 sec of exposure time were used. We quantitatively analyzed the images using the Living Image 4.5 software., there are two main sources of motion in kidney imaging: respiration and cardiac pulsation.
$$\left[\begin{array}{c}{C}_{{{{{{{\mathrm{HbR}}}}}}}}\left\\ {C}_{{{{{{{\mathrm{HbO}}}}}}}_{2}}\left\\ {C}_{{{{{{{\mathrm{exo}}}}}}}}\left\end{array}\right]={\left}^{-1}{\varepsilon }^{T}P^{\prime},$$\\\ P^{\prime} \left\\ \begin{array}{c}\vdots \\ P^{\prime} \left\end{array}\end{array}\right]\)\ & {\varepsilon }_{{{{{{{\mathrm{HbO}}}}}}}_{2}}\left & {\varepsilon }_{{{{{{{\mathrm{exo}}}}}}}}\left\\ {\varepsilon }_{{{{{{{\mathrm{HbR}}}}}}}}\left & {\varepsilon...
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