'Binocular' treatment followed by sleep found to help with a common vision problem umich CommsBio
. Here, in side-by-side comparison of the effects of brief binocular vs. monocular recovery experiences in mice, we show the two have strikingly different effects on bV1 ocular dominance and network activation in bV1. These data reflect findings using comparisons of 24-h binocular vs. monocular recovery, where simply re-opening the DE in mice was found to be more efficacious for restoring binocular vision than RO.
, we hope that our present data will inform future strategies for optimizing amblyopia treatment in children.All mouse husbandry and experimental/surgical procedures were reviewed and approved by the University of Michigan Internal Animal Care and Use Committee. Weaned C57BL6/J mice were housed in a vivarium under 12 h:12 h light/dark cycles with littermates starting postnatal day 21 and hadaccess to food and water.
For all experiments, male littermates were randomly assigned to treatment groups. For monocular deprivation , mice were anesthetized at P28 using 1–1.5% isoflurane. Nylon non-absorbable sutures were used to occlude the left eye. Sutures were checked twice daily to verify continuous MD; during this time they were handled 5 min/day. After MD , mice were anesthetized with 1–1.5% isoflurane a second time and left eyelid sutures were removed.
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