Uncovering the causes of neuron dysfunction in Huntington'sdisease northwesternu NatureComms
Stereotaxic-guided surgeries were performed on mice anesthetized with isoflurane. After positioning the head to obtain a flat skull between bregma and lambda, a small hole was drilled with a micro drill, and a glass pipette was slowly inserted at the following coordinates. Primary motor cortex injection coordinates were reached using a computer-guided stereotaxic instrument with atlas integration and were : 1.2 mm AP, 1.6 mm ML, and −1.4 mm DV. For cingulate cortex : 1.34 mm AP, −0.
Patch pipettes were prepared with a Sutter Instruments horizontal puller using borosilicate glass with filament and filled with the internal solution mentioned above. Access resistances were continuously monitored, and experiments were discarded if changes >20% were observed. Digitized data were imported for analysis with commercial software .
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Type I interferon shapes brain distribution and tropism of tick-borne flavivirus - Nature CommunicationsHere the authors combine a multimodal imaging-snRNAseq transcriptomics strategy to provide insight into the distribution of a neurotropic tick-borne flavivirus in the brain, and show that absence of interferon signaling increases infection of resident microglia.
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Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization - Nature CommunicationsThe molecular clock REV-ERBα regulates lung injury during fibrosis, but the role of REV-ERBα in fibrogenesis remains unknown. Here, the authors show that REV-ERBα interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrate the therapeutic potential of Rev-erbα agonist against lung fibrosis.
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New fund launched to bring nature back to life in NIOver three quarters of Northern Irish folks are worried about the impact nature loss will have on their lives, according to a YouGov survey
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Study links poor diet to 14 million cases of type 2 diabetes globallyA research model of dietary intake in 184 countries, developed by researchers at the Friedman School of Nutrition Science and Policy at Tufts University, estimates that poor diet contributed to over 14.1 million cases of type 2 diabetes in 2018, representing over 70% of new diagnoses globally. The analysis, which looked at data from 1990 and 2018, provides valuable insight into which dietary factors are driving type 2 diabetes burden by world region. The study was published April 17 in the journal Nature Medicine.
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