Researchers will need fewer mice to study lung infections thanks to improvements in dosing methods, according to a new study from the University of California San Francisco (UCSF). Changing how animals are anesthetized and infected with microbes allows scientists to study lung infections using smaller group sizes and without having to use invasive dosing methods. The study is published in the American Journal of Physiology-Lung Cellular and Molecular Physiology.
"Optimized dosing methods allow researchers to complete mouse studies faster and at lower cost," said Simon Cleary, Ph.D., a postdoctoral scholar at UCSF and a lead author of the study.
"Making preclinical studies more efficient in this way has potential to speed up the development of new and improved treatments for patients. Researchers switching to less invasive methods that mean fewerElizabeth A. Townsend et al, P2X7 signaling influences the production of pro-resolving and pro-inflammatory lipid mediators in alveolar macrophages derived from individuals with asthma,
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Cancer surgery survivor helping researchers in new studySharon Applin had all the organs in her pelvis removed and wants her experience to aid other patients.
Weiterlesen »
Researchers develop novel method using MRI to study diseases modeled in zebrafishZebrafish have revolutionized research into a wide variety of rare and complex genetic diseases. In early development stages, their transparent bodies allow researchers to more easily study tissues and organs. However, studying organ-level defects in adult zebrafish presents a variety of challenges that prevent researchers from studying them at a microscopic level.
Weiterlesen »
University of Arkansas receives $3.1 million NIH award to study pediatric mitochondrial disordersThe Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded $3.1 million to the University of Arkansas to study a spectrum of pediatric mitochondrial disorders caused by mutations in the mitochondria.
Weiterlesen »
Researchers identify inherited gene mutation linked to esophageal cancerStudying genes in families with a propensity for certain diseases has led to many critical advances in medicine, including the discovery of statins in family members who suffered heart attacks at an early age.
Weiterlesen »
Researchers identify neurons that guide flies upwindNew research by Janelia scientists and collaborators at the University of North Carolina at Chapel Hill shows how a cluster of neurons in the fruit fly brain transforms memories about past rewards into actions, helping the fly navigate to find food. The findings are published in the journal eLife.
Weiterlesen »
Adolescent girls were severely affected by pandemic stress, find researchersA new study led by researchers at Western and Lawson Health Research Institute has found that adolescent emergency department (ED) visits and hospitalizations for suicidal thoughts, self-harm and self-poisoning increased across Canada during the COVID-19 pandemic, especially among adolescent girls.
Weiterlesen »