Zebrafish have revolutionized research into a wide variety of rare and complex genetic diseases. In early development stages, their transparent bodies allow researchers to more easily study tissues and organs. However, studying organ-level defects in adult zebrafish presents a variety of challenges that prevent researchers from studying them at a microscopic level.
over the first week of life. This rapid development and ability to remove their body wall pigment during this early period enables scientists to microscopically image whole organs and perform accurate time-lapse analyses of disease progression. They can also screen drug candidates that may be used to treat various illnesses, since the zebrafish can absorb the drug through their gut, skin, or thin gills.
"MRI technology is widely used for a variety of clinical and research applications, and as zebrafish become a more preferred model for translational research, we wanted to explore how this technology could improve the research we are doing in these animal models," said first study author Sonal Sharma, MD, awithin the Division of Neurology and the Mitochondrial Medicine Frontier Program in the Division of Human Genetics at CHOP.
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