Studies examine heat and cold as cardiovascular health hazards SciReports
The ambient conditions throughout the whole study were simulated using data from a 3-day HW of similar intensity in Slovenia. The 24-h ambient temperature within the facility did not mimic the sinusoidal change in ambient temperature observed in the mentioned HW but maintained the diurnal and nocturnal temperatures in the work and rest areas at average temperatures.
, none of the participants requested premature cessation during HUT or showed haemodynamic signs of presyncope.Cardiovascular parameters: Heart rate was determined from Lead II electrocardiogram. Arterial pressure was measured, in duplicate, via electro-sphygmomanometry with a microphone placed over the brachial artery at the heart level to detect Korotkoff sounds, while the arm was parallel to the body.
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Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation - Nature CommunicationsAntibodies targeting sclerostin can ameliorate postmenopausal osteoporosis but present some cardiovascular risk. Here the authors show that the cardiovascular and skeletal effects of sclerostin are mediated by different loops, suggesting ways to preserve the positive effects on bone formation while avoiding the negative cardiovascular consequences.
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Population, Clinical, and Scientific Impact of National Cancer Institute's National Clinical Trials Network Treatment Studies | Journal of Clinical OncologyPURPOSE In the United States, the National Cancer Institute National Cancer Clinical Trials Network (NCTN) groups have conducted publicly funded oncology research for 50 years. The combined impact of all adult network group trials has never been systematically examined. METHODS We identified randomized, phase III trials from the adult NCTN groups, reported from 1980 onward, with statistically significant findings for ≥ 1 clinical, time-dependent outcomes. In the subset of trials in which the experimental arm improved overall survival, gains in population life-years were estimated by deriving trial-specific hazard functions and hazard ratios to estimate the experimental treatment benefit and then mapping this trial-level benefit onto the US cancer population using registry and life-table data. Scientific impact was based on citation data from Google Scholar. Federal investment costs per life-year gained were estimated. The results were derived through December 31, 2020. RESULTS One hundred sixty-two trials comprised of 108,334 patients were analyzed, representing 29.8% (162/544) of trials conducted. The most common cancers included breast (34), gynecologic (28), and lung (14). The trials were cited 165,336 times (mean, 62.2 citations/trial/year); 87.7% of trials were cited in cancer care guidelines in favor of the recommended treatment. These studies were estimated to have generated 14.2 million (95% CI, 11.5 to 16.5 million) additional life-years to patients with cancer, with projected gains of 24.1 million (95% CI, 19.7 to 28.2 million) life-years by 2030. The federal investment cost per life-year gained through 2020 was $326 in US dollars. CONCLUSION NCTN randomized trials have been widely cited and are routinely included in clinical guidelines. Moreover, their conduct has predicted substantial improvements in overall survival in the United States for patients with oncologic disease, suggesting they have contributed meaningfully to this nation's health. These find
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Titanic's James Cameron to prove Jack couldn't have survived'We have done a scientific study to put this whole thing to rest.'
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Reports of burst pipes double across Scotland due to freezing temperaturesScottish Water said its network has seen demand for an additional 100 mega litres since Thursday as a result of broken pipes
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Emergency services called to reports of man on bridge near HMP Forest BankPolice and paramedics rushed to the scene
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Eagles' Jalen Hurts sprained shoulder vs. BearsJalen Hurts suffered a sprained shoulder that’s not considered a long-term injury Sunday in the Eagles' game against the Bears, a league source confirmed to ZBerm and Bo_Wulf. Early indications are that Hurts could be out for the next two weeks.
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