Calorierestriction slows pace of aging in healthyadults ColumbiaMSPH NatureAging
of aging and extend healthy lifespan" says senior author Daniel Belsky, Ph.D., associate professor of epidemiology at Columbia Mailman School and a scientist with Columbia's Butler Aging Center."Our study aimed to test if calorie restriction also slows biological aging in humans."
In the primary analysis Belsky and colleagues focused on three measurements of the DNA methylation data, sometimes known as"epigenetic clocks". The first two, the PhenoAge and GrimAge clocks, estimate, or the chronological age at which a person's biology would appear"normal". These measures can be thought of as"odometers" that provide a static measure of how much aging a person has experienced.
Our study found evidence that calorie restriction slowed the pace of aging in humans" Ryan said."But calorie restriction is probably not for everyone. Our findings are important because they provide evidence from athat slowing human aging may be possible. They also give us a sense of the kinds of effects we might look for in trials of interventions that could appeal to more people, like intermittent fasting or time-restricted eating.
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