Changes in brain aerobic glycolysis reflect aging-related pathologies in Alzheimer’s Aging Brain Neurology Glycolysis Alzheimers Disease Glycolysis PNASNews WUSTLmed
By Bhavana KunkalikarFeb 8 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Proceedings of the National Academy of Sciences, researchers explore aerobic glycolysis in the brain and its resilience during Alzheimer's disease .
AD also impacts AG in the human brain. In fact, early AD is related to a large decline in glucose consumption rates in comparison to a lesser shift in oxygen consumption. For each PET assessment and metabolic estimate , a "youthful pattern" was described according to its association with average regional values. These values reflected gray matter assessed in a distinct but re-processed dataset consisting of a group of young and healthy adults between 20 and 34 years of age in the N33 cohort. The N33 cohort was used to determine the youthful trend related to each metabolic characteristic.
Further study revealed a significant interaction between gender and age, wherein the youthful GI index decreased more rapidly for men than women as they aged. Considering these results, age and gender were included as factors in subsequent analyses.
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