A 🆕 blood test that analyzes DNA shed by metastatic cancers could reveal characteristics unique to each patient's tumor and allow physicians to develop more personalized treatment plans, according to a new report.
Blood-based biopsy technology, also known as"liquid biopsy," has emerged as a tool for clinical cancer genotyping and longitudinal disease monitoring. Tests that use ctDNA have begun to influence the clinical management of people with cancer, the study authors write, though the full potential for understanding metastatic cancer biology hasn't yet been unlocked.
The researchers assessed all classes of genomic alterations and found that ctDNA contains multiple dominant populations, indicating that most people with metastatic cancer have different metastases spread around the body. They found that the whole-genome sequencing process provides a host of information about these different metastases.
The researchers studied multiple ctDNA samples collected over time to understand how a patient's cancer evolved in response to treatment. They focused on inhibitors of the androgen receptor pathway. They found that current therapies foractively change the composition of cancer populations in the body and that treatment often selects for biologically aggressive cancer populations that underlie clinical resistance.
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