Change in breastdensity over time linked to cancer risk wustl JAMAOnc
We hypothesized that there is a difference in the rate of change in breast density in women who subsequently develop breast cancer compared with those who do not. Using longitudinal, quantitative data captured for up to 10 years, we evaluated the association between rate of change in mammographic density and risk of breast cancer development.Ethical approval for this prospective nested case-control cohort study was obtained from the Washington University in St Louis institutional review board.
Follow-up was conducted by linking to electronic health records, a tumor registry, and a death register. Routine screening mammograms were obtained every 1 to 2 years. A total of 8908 of the 10 481 women in our cohort had either a mammogram or clinic visit within the last 3 years of follow-up .Analytic Data Set
We sampled 2 control participants for each case patient according to age at cohort entry and year of enrollment. Incident breast cancers were identified through record linkage to pathology and tumor registries. We identified 347 cases and 694 controls.
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