Old antipsychotic drugs may offer new option to treat type 2 diabetes ualberta
mice, floxed SCOT mice, and their Cre/floxed SCOT–negative wild-type littermates fed an HFD indicate that nestinmice do exhibit improved insulin sensitivity with no change in fasting glucose levels, as well as a generalized growth defect . As the DPBPs were still capable of improving glucose tolerance in nestinmice, this suggests that brain SCOT activity and ketone oxidation regulate glycemia even if nestinmice harbor these metabolic phenotypes.
In summary, our study has demonstrated that not only pimozide but the DPBP drug class in general are also SCOT inhibitors. Through these actions and not their ability to inhibit Dreceptors, they induce potent glucose lowering in obesity.
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