Patients with alcohol-related cirrhosis have a higher fracture rate and a higher post-fracture mortality rate compared with the general population, according to a large new study. LiverTwitter
The association between liver cirrhosis and fractures appears strongest in patients with alcohol-related cirrhosis, the most common cause of cirrhosis in many countries, including Sweden, the authors write.
Overall, 48,635 fractures occurred during 3.4 million person-years of follow-up, including 3659 among patients and 44,976 among controls. Among those with a fracture, the median time to death was 2.8 years in patients with alcohol-related cirrhosis and 3.5 years in controls. “The data emphasize that a fall and fracture herald a time of increased risk,” he said. “Research is needed to develop interventions that prevent falls and help patients remain more resilient when they happen.”Osteoporosis was the most common presumed mechanism in both patients with alcohol-related cirrhosis and controls , while high-energy trauma from motor vehicle crashes or heights preceded 10.9% of fractures in patients and 13.5% in controls.
In addition, the post-fracture mortality rate in those with osteoporosis was more than double in patients with cirrhosis in the first 30 days after a fracture and more than tripled after one year.
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