Sleep behaviors are associated with an increased risk of developing metabolic-dysfunction associated fatty liver disease.
MAFLD was diagnosed in 28% of the study population. They were older, more likely to be female with a higher education, and had a higher prevalence of preexisting metabolic disorders, and worse metabolic profiles, than those without the disease.
However, after adjusting for demographics, lifestyles, medication and preexisting metabolic comorbidities including hypertension, diabetes and obesity, they found that the risk of MAFLD was significantly associated with late bedtime , at an odds ratio of 1.37 . When the team compared low-risk and high-risk sleep factors, they found that participants who had an early bedtime, slept 7-8 hours per night, never or rarely had insomnia or snoring, had infrequent daytime sleepiness, and daytime napping of half-hour or less had an odds ratio for MAFLD vs other participants of 0.64 .
In contrast, individuals with poor nocturnal sleep patterns and prolonged daytime napping had a higher risk for developing MAFLD vs those with a healthy nocturnal sleep pattern and daytime napping of half-hour or less, at an odds ratio of 2.38 .
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