In ophthalmology, there are several approved, biotechnologically manufactured, regenerative medicine products that are used as eye drops or as transplants for corneal diseases.
Gerd Geerling, MD, PhD, professor of ophthalmology at University Hospital Düsseldorf, Germany, and president of the German Ophthalmological Society , presented the methods, indications, and therapeutic options at a press conference ahead of this year's DOG congress.
"The approval studies demonstrated that after 8 weeks of therapy, complete epithelial closure was achieved in 72% of patients, compared with just 33% in the control patients," said Geerling. The European Medicines Agency approved the product based on the evidence that it increased the number of patients who achieved complete healing of the eye's surface by around 30% to 40%, compared with eye drops without the active substance.
This corrects the keratoconus-related thinning and deformation, as well as the corneal distortion. A corresponding implant is approved in Germany but still requires careful clinical testing.Therapy with cell-populated artificial tissue may be considered if there has been a loss of natural epithelial regeneration in the corneal limbus, such as after a burn on the eye's surface.
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