A diverse menu of vaccine options leaves people searching for the best route to protection.
, but it’s unclear how much, if any, extra protection against illness this will produce. Neutralization data for BA.4- and BA.5-specific vaccines aren’t expected until around mid-September.
“If we had an immunologically naive population of people who had not been infected or vaccinated, it would make absolute sense for the vaccine to be from the Omicron lineage,” he says. “But how many people are neither infected nor vaccinated?” In countries such as the United States, people eligible for a booster in the summer have been wrestling with a decision: take a booster shot of the original vaccine, or wait a few more months for a version containing Omicron-specific spike.that the decision should be a personal one, and people should factor in whether they’re at risk of serious disease, their community’s infection rate and how well they can shield themselves from SARS-CoV-2.
One study found that the antibody response to vaccination was weaker in people who had high antibody levels prior to getting the shot than in people with lower levels of pre-vaccination antibodies. This is not a surprise to immunologists, says study author and viral immunologist Pablo Penaloza-MacMaster at Northwestern University Feinberg School of Medicine in Chicago: circulating antibodies might clear the spike protein in the vaccine before the immune response has a chance to be boosted.
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