When COVID meets Candida: exploring the alarming surge of C. auris in Israel CDC_NCEZID candida candidauris Cauris fungalinfection isreal covid COVID19 hospitalization
By Tarun Sai LomteJun 13 2023Reviewed by Lily Ramsey, LLM A recent study published in Emerging Infectious Diseases reported an outbreak involving Candida auris in Israel.
Subsequently, surveillance efforts were initiated, and clinical isolates were referred to a national laboratory for further testing. While surveillance indicated a low incidence, the number of isolates has increased since January 2021. Polymerase chain reaction and sequencing of ribosomal DNA’s internal transcribed spacer and D1/D2 regions were performed. Antifungal drug susceptibility was tested by broth microdilution.
Related StoriesH1 reported 128 C. auris isolates. Repeat cultures in 152 patients indicated C. auris colonization for 14 days. C. auris incidence in 2021-22 corresponded with the surge in coronavirus disease 2019 cases. The antifungal susceptibility rates were 15.6%, 79.6%, 86.4%, 98% for fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. Twenty-one isolates were fluconazole- and amphotericin B-resistant, while two were anidulafungin-, amphotericin B-, and fluconazole-resistant. All clade III isolates were fluconazole-resistant compared to 63% of the remaining isolates.
In total, 70 in-hospital deaths occurred. The researchers further assessed C. auris outbreak evolution in three hospitals .
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