What You Need to Know About COVID-19 Booster Doses

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What You Need to Know About COVID-19 Booster Doses
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The what, when, why, where and how of additional COVID-19 vaccine doses

reported in July

that early studies involving people who were given a third dose about six months after their second dose showed strong antibody responses five to 10 times higher than levels after two doses. Based on those results, the companies have requested that the U.S. Food and Drug Administration approve a booster dose of its vaccine.

While the vaccine makers are understandably eager to sell an additional dose of their shots, the FDA said in athat boosters for the U.S. are premature at this point. “FDA, [Centers for Disease Control], and [the National Institutes of Health] are engaged in a science-based, rigorous process to consider whether or when a booster might be necessary…We are prepared for booster doses if and when the science demonstrates that they are needed.

Moderna is testing three different third dose strategies: a half-dose of the existing vaccine, an additional dose of a new vaccine that targets the Beta variant, and another dose that combines the existing and Beta variant shots.that serum from people given the half dose of the existing vaccine neutralized SARS-CoV-2 variants at levels similar to or higher than those against the non-variant strain.

The agency will also likely consider the state of the pandemic; specifically, whether the threat of new variants, including Delta, calls for the need for another dose.It’s not clear yet where the booster doses, if they are authorized, will be distributed.

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