What is the impact of SARS-CoV-2 on HIV-1 infectivity? researchsquare KUMedCenter SARSCoV2 COVID19 HIV Infectivity
By Bhavana KunkalikarOct 31 2022Reviewed by Aimee Molineux In a recent study posted to Research Square* preprint server, researchers assessed the effect of severe acute respiratory syndrome coronavirus 2 and SARS-CoV envelope proteins on human immunodeficiency virus type 1 infectivity.
The team first assessed the SARS-CoV-2 E protein's intracellular expression. The SARS-CoV-2 E protein was expressed in COS-7 cells using a vector marked at the C-terminus with a hemagglutinin tag. The E protein was then immunostained using anti-HA antibodies as well as antibodies against LAMP-1 , endoplasmic reticulum -Golgi intermediate compartment , and Golgin97 .
The team observed that co-transfection with vectors encoding the vpu HIV-1 genome, BST-2, and the SARS-CoV-2 E protein reduced the infectious virus produced, though not as significantly as the HSV-1 gD protein. Immunoblots of the cell lysates for gD, BST-2, and the SARS-CoV-2 E protein demonstrated that these proteins showed significant expression during the co-transfections.
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