Disease-causing pathogens are notoriously dangerous foes that have evolved many tricks to thwart the body's immune system. Among the most terrifying are ones that can sneak into the nervous system, even infecting the brain.
C. neoformansfungal spores are depicted in fluorescent yellow.
In the zebrafish, blockages not only increased local blood pressure but as blood flow backed up, the fungal obstruction also increased the tension of the walls of nearby blood vessels, making them more prone to rupture."Previous research has focused on how microbes can break down the defenses of the brain or use immune cells as a route into the brain,"
"Infections causing meningitis can be treated with antimicrobials, but patients are often very ill and a lot of damage can be caused before treatment is effective,"Hopefully, understanding how fungal meningitis spreads in the brain will lead to new therapies that help limit damage to the brain's blood vessels while antifungal treatments work to clear the infection.
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