Neuroscientists at the Medical University of South Carolina use a novel brain imaging technique to visualize subtle brain changes in pre-symptomatic Alzheimer’s patients. Neuroscientists from the Medical University of South Carolina (MUSC) report in the journal Brain Connectivity that they have d
Neuroscientists at the Medical University of South Carolina have discovered subtle differences in brain function among older adults with preclinical Alzheimer’s disease using a novel brain imaging analysis technique. These individuals show the earliest signs of AD, like the buildup of amyloid-beta proteins, but exhibit no noticeable cognitive decline symptoms. The researchers, led by Dr. Andreana Benitez and Dr.
Adults with preclinical AD have the earliest signs of disease, such as the buildup of amyloid-beta proteins in their brains. However, they have no noticeable symptoms of cognitive decline. They looked at brain activity using a functional connectome – a type of brain map that measures how different brain regions communicate with one another. Think of the brain like a big city, said Fountain-Zaragoza, where brain regions are clustered into neighborhoods connected by highways. The functional connectome is like watching the activity across that city – how much there is going on within each neighborhood and how well traffic flows between them.
Traditional functional connectomes use an average of many people’s brains as a map for functional brain regions. In contrast, Liu’s method can show the unique patterns of brain function for each individual. In participants with preclinical AD, information processing was worse in those with greater than usual between-network connectivity, or too much activity on the brain’s highways. In contrast, information processing was better in those with higher within-network connectivity, or more brain activity within important neighborhoods of the brain.
It also suggests that the early stages of amyloid-beta buildup could affect the function of brain networks even before symptoms of cognitive decline become noticeable.
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