Unlocking the link: COVID-19 restrictions tied to surge in invasive Group A Streptococcal infections Eurosurveillanc covid COVID19 SARSCoV2 streprococcal streptococcalA GAS
By Pooja Toshniwal PahariaJul 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in Eurosurveillance, researchers investigated whether a change in variant structure might be responsible for the increased incidence of group A streptococci infections of invasive and non-invasive types in winter 2023 or whether this can be better understood through the effect of coronavirus disease 2019 -associated limitations on group A streptococci transmission and immunity in the population.
About the study In the present study, researchers examined current genetic advancements and the effect of new strain emergence on iGAS infection incidence in 2023. The researchers collected GAS-positive cell culture reports from 2018 onward and grouped them as invasive GAS if the specimen originated from synovial fluid, blood, peritoneum, pleural fluid, spinal fluid, or sterile tissue, and non-invasive GAS if the strain in question had been of any other type of specimen or non-sterile tissue.
Results In total, 1,265.0 iGAS infections were identified between 2018 and May 2023 among six million Danish individuals. However, the highest rise relative to pre-pandemic limitations was noted among pediatric individuals under five years, peaking at 3.20 cases among 100,000 children in March of 2023. Death rates were comparable to those observed in prior years across ages, with 30.0% among older individuals aged ≥85 and below 5.0% among those under five years.
The M1 ST28/EMM-1 and the ST36/EMM-12 clones were identified most frequently as the etiological agents of invasive GAS infections in winter 2023, responsible for 57% and 24% infections, respectively, from January to February of 2023.
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