Unlocking the link between sleep disturbances, lipids, and autism: Can diet make a difference? Autism Genetics Lipidomics AutismResearch Sleep CognitiveFunction Neurodevelopment ASDdiagnosis HealthyDiet Microbiome NatureMedicine
By Bhavana KunkalikarApr 24 2023Reviewed by Benedette Cuffari, M.Sc. Autism spectrum disorder is a neurodevelopmental condition that is marked by communication and social difficulties, restricted and repetitive activities, and sensory sensitivity variations. Sleep difficulties, eating disorders, gastrointestinal issues, anxiety, and seizures are frequent co-occurring conditions with ASD.
About the study In the present study, researchers utilize biological and phenotypic data to evaluate links between the plasma lipidome and autism-related characteristics. The possible impacts of environmental variables on neurodevelopment-related lipidome patterns were explored. Principal component analysis was used to assess LWAS relationships, whereas PC1 allowed the researchers to encapsulate a trait's lipidome characteristics in a single variable.
Lower IQ/DQ was correlated to the usage of antiepileptic drugs, sleep medicines, and fish oil/DHA supplements. Furthermore, sleep disruptions were linked to ADHD/behavioral drugs and sleep medications. The researchers also discovered lipid species that were significantly related to ASD diagnosis, sleep disturbance, and IQ/DQ. Multiple species-level relationships with age, BMI, Tanner stage, and gender that corresponded to the associations seen in the variance component analysis were also observed.
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