Myokine has been demonstrated to enhance both the growth of myoblasts and the contractile power of myotubes. Researchers at Tokyo Metropolitan University have found that skeletal muscle cells continuously secrete a protein called platelet-derived growth factor subunit B (PDGF-B), which aids in musc
The researchers discovered that PDGF-B enhances not only muscle growth but also strengthens them.
Unexpectedly, the scientists discovered that PDGF-B also promotes the growth of muscle fibers, leading to stronger contractions. These findings hold great potential for the development of innovative treatments for muscular atrophy and injury. A team led by Associate Professor Yasuko Manabe at Tokyo Metropolitan University has been studying how myokines affect the behavior of muscle cells. Through extensive experiments, they found that a myokine known as platelet-derived growth factor subunit B, or PDGF-B, is secreted by skeletal muscles in a constitutive way i.e. without any stimulus. To understand what role it plays, they took myoblasts, precursor cells which go on to differentiate into muscle fibers, and exposed them to PDGF-B.
Curiously, they also found that PDGF-B impacted cells which had already differentiated. They took myotubes, a developmental stage of muscle fibers, and exposed them to the same myokine. Myotubes treated in this way exhibited significantly more maturation, visibly increasing in diameter under microscope observation. They also expressed more Myosin Heavy Chain, a key part of the protein structure of myosin, the molecular motor responsible for muscle contraction.
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