A draft report from a U.S. biosecurity panel examining “gain-of-function” research policies has recieved mixed responses from outside experts.
, released today, also recommends funding agencies share more information about decisions to approve such work.
Concerns over GOF studies exploded 12 years ago when two researchers reported that they had tweaked H5N1 avian influenza in ways that made the virus spread more easily between ferrets, a model for human transmission. Although the work was meant to help prepare for pandemics, some experts worried such a souped-up virus could escape from the lab or be released deliberately, potentially sparking a pandemic.
The apparent rationale for that language is to exempt routine GOF research on viruses that don’t usually cause serious disease, such as herpes viruses and cold viruses. But it’s unclear whether other standard studies, such as tweaking seasonal flu viruses to find out whether new mutations are helping them spread, could now require P3CO review, says Andrew Pekosz, a flu researcher at Johns Hopkins University. “I still have a lot of concerns,” he says.
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