Despite a 25% reduction in TGs along with similar reductions in VLDL, and remnant cholesterol, a novel agent failed to provide any protection in a multinational trial against a composite endpoint of MACE in patients with T2D. AHA22 MedTwitter
Despite a 25% reduction in triglycerides along with similar reductions in very-low-density lipoprotein , and remnant cholesterol, a novel agent failed to provide any protection in a multinational trial against a composite endpoint of major adverse cardiovascular events in patients with type 2 diabetes.
In the setting of good control of LDL cholesterol,"fibrates have not been shown to further lower CV risk," said Dr. Watson, who was invited by the AHA to discuss the PROMINENT trial. The patients were eligible if they had TG levels from 200 to 400 mg/dL and HDL cholesterol levels of 40 mg/dL or below. Pemafibrate in a dose of 0.2 mg or placebo were taken twice daily. About two-thirds had a prior history of coronary heart disease. The goal was primary prevention in the remainder.
Furthermore, pemafibrate was associated with a median 27.6% reduction relative to placebo in apolipoprotein C-III and a median 4.8% reduction in apolipoprotein E, all of which would be expected to reduce CV risk.immediately after their presentation .
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