Towards Zika preparedness: immunogenicity insights from vaccine research TheLancetInfDis zika zikavirus vaccine zikavaccine zikavirusvaccine
By Neha MathurJun 30 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Lancet Infectious Diseases, researchers performed a phase I randomized clinical trial between November 7, 2016, and October 30, 2018, in the United States of America to assess the safety and immunogenicity of an inactivated Zika virus vaccine candidate.
The Zika virus was endemic in sub-Saharan Africa and the Indian Ocean basin for decades. Much later, scientists discovered that it was a pathogen of public health importance because it caused severe congenital defects and neurological disorders. About the study For this phase I, double-blind, placebo-controlled trial, researchers recruited 18 to 49-year-old adults with no previous flavivirus exposure , confirmed by a microneutralization assay. The study cohort did not have pregnant females and individuals with serological evidence of human immunodeficiency virus , hepatitis B, or hepatitis C infections.
The team analyzed primary study outcomes, i.e., systemic, local adverse events, serious adverse events , and adverse events of special interest , in recipients of at least one ZPIV or placebo dose. They assessed solicited adverse events up to seven days post-vaccination and unsolicited adverse events up to day 28 after vaccination.
A microneutralization titer of 1:10 or more indicated seropositivity, i.e., Zika virus-specific nAbs and nAbs against yellow fever and Japanese encephalitis viruses, before and after ZPIV vaccination. flavivirus naive, IXIARO-primed, and YFVAX-primed groups. Based on one-year follow-up data, it also posed no significant safety issues.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Man Utd report: Ten Hag 'against selling' Greenwood as Red Devils boss 'leans towards' decisionMan Utd boss Erik ten Hag is reportedly reluctant to let Mason Greenwood leave on a permanent basis this summer, preferring a loan move.
Weiterlesen »
Man accused of raping elderly woman tells jury she made advances towards himStanley Ekhator is on trial at Minshull Street Crown Court accused of raping a care home resident with dementia
Weiterlesen »
David Linden: Let's work towards a future where everyone can thrive'We still have so much further to go to rid society of the minority of folks who hold dinosaur-like views when it comes to LGBT rights' | DavidLinden ✍️
Weiterlesen »
Liverpool make step towards deal for Szoboszlai with Newcastle uninterestedLiverpool are in advanced talks with RB Leipzig for attacking midfielder Dominik Szoboszlai, talkSPORT understands. The Hungary captain has a £60million release clause in his contract, but that is …
Weiterlesen »
New study reveals alarming cognitive impairments in long COVID patientsPersistent COVID-19 symptoms can lead to cognitive deficits in recovered patients. This systematic review highlights the need for further research and interventions to address long-term cognitive impairments.
Weiterlesen »
Study reveals unhealthy eating habits and poor sleep quality among female college studentsUnhealthy eating habits and alcohol consumption among female health science college students revealed in a cross-sectional study, highlighting the need for nutritional education and lifestyle interventions. Macronutrient imbalances, poor sleep quality, and low adherence to the Mediterranean diet were observed.
Weiterlesen »