Researchers create digital map of sympathetic nervous system UCF SciReports
. In the LA, the highest density of TH-IR axons were observed at the entrance of PV to the LA. The junction of the left atrium and pulmonary veins has been indicated to be a focal source which is responsible for the initiation of atrial fibrillation. Therefore, further functional studies of these great vein-atrial junction regions, which were the most dense with TH-IR axons in our quantitative analysis, are valuable to better understand the physiology and pathology of atrial fibrillation.
Considering that understanding how sympathetic neurons communicate to their cardiac targets is essential for understanding how the heart works , our results provide a basis for understanding the role that TH-IR axons specific innervation play in the control of the normal heart as well as in the diseased heart.Neurolucida 360 TH-IR axon tracing: Despite our effort to trace TH-IR axon bundles and their projection field, it was not feasible to trace the smallest branches and individual axons in the whole atria.
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