A new kind of “edgeless” engineered tissue can fit any irregular shape, paving the way for hand and face grafts that look and move better.
One faction wanted to grow a face, but the faction that wanted to try a hand won. They imagined a five-fingered structure that could be snipped open at the wrist, slid on like a glove, then sutured. “You would only have to apply bandages around the wrist area—and that would be the surgery,” Abaci says.
“The way they got this to work was pretty exciting,” says Adam Feinberg, a biomedical engineer at Carnegie Mellon. “We're on a path to these technologies being more broadly available. Ultimately, in another decade or so, it's going to really change how we're able to repair the human body after injury or disease.”
Sashank Reddy, a plastic surgeon and tissue engineer at Johns Hopkins University, points out that the team can also grow these structures from very small biopsies, rather than having to transplant a large quantity of tissue from somewhere else on the patient’s body. “Say I had to resurface someone's entire forearm—that's a lot of skin that I have to borrow elsewhere from their body, from their back or their thigh,” Reddy says.
Abaci sees potential to use this engineered skin for testing drugs and cosmetics, and for studying the fundamental biology of skin. But the main draw for him is creating transplants—ideally ones that can go on as a single wearable piece and might be engineered with the help of other research groups that specialize in muscle, cartilage, or fat.
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