Autologous haematopoietic stem cell transplantation (aHSCT) aims to kickstart a patient’s immune system
A therapy normally used to treat blood cancers by “resetting” the immune system could slow the progression of a common form of multiple sclerosis , a study suggests. Researchers said they hope the treatment could be “included as a standard of care” in treating MS in the future.
However, after each relapse, their disability can end up worse than before. The research team recruited 231 patients, 174 of which had been treated with aHSCT before 2020. Following the therapy, the average relapse rate was one every 30 years. The team said its findings, published in the Journal of Neurology Neurosurgery and Psychiatry, “demonstrate that aHSCT for is feasible within regular healthcare and can be performed without compromising safety”.
Dr Alena Pance, a senior lecturer in genetics at the University of Hertfordshire, said: “The disability caused by MS is the result of damage or degradation of the myelin that envelops and protects the nerves of the central and peripheral nervous system.
However, she cited a trial comparing aHSCT and disease-modifying therapy , which showed “similar positive effects of aHSCT in terms of prolonged time to disease progression and better outcomes than DMT”. “More than 130,000 people live with MS in the UK and there are multiple treatments available, but we still don’t know enough about how the effectiveness of HSCT compares with the most effective DMTs.”
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