Simultaneous diagnosis and treatment of cancer now possible postech2020
]. Interestingly, at an increased concentration, TiY also showed selective cytotoxicity to the TIC over non-TIC cancer and normal epithelial cells, suggesting its validity in theranostics application through the dual potential in TIC selective visualization and therapeutic effect. Nevertheless, the in vivo applicability of TiY has yet been addressed.
In this study, we demonstrated the utility of TiY for targeting TIC in vivo. With the aggressive lung cancer models, we assessed TiY for TIC selective staining and the therapeutic effect in the mouse models. Repeated treatment of TiY inhibited tumor formation by targeting vimentin-positive cells in tumors with low toxicity to normal cells. We finally elucidated the molecular mechanism of selective toxicity to TIC in terms of vimentin dynamics.
]. Human dermal fibroblast cells were maintained in DMEM containing 10% FBS and 2 mM L-glutamine 1% antibiotics. The fibroblast cell line was passaged by trypsin-EDTA digestion, and the fresh medium was replenished every 3 days.Cells were incubated with antibodies against CD166-Cy5 or TiY at the concentration of 1 μg / mL and 10 nM in 1 mL of DPBS containing 2% FBS and antibiotics containing 1 × 10cells for more than 40 min at 4°C. The cells were washed and resuspended in the DPBS-S.
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